# Survival, cells and the preparations studied

> Epitalon bibliography — Keystone Peptide — The Keystone Peptide reading list: Epitalon survival and cell experiments, the human Epithalamin cohort and a review of proposed mechanisms.

**Reading list**

The mouse experiment is the starting point. The cell findings and the human follow-up make the argument more complicated.

## Starting with survival

The [female SHR mouse paper](https://pubmed.ncbi.nlm.nih.gov/14501183/) is the best introduction to the argument here because its maximum and mean lifespan findings pull attention in different directions. The [human follow-up](https://pubmed.ncbi.nlm.nih.gov/14523363/) is worth opening alongside it, with Epithalamin still in its name.

For the cellular work, the [fetal fibroblast experiment](https://pubmed.ncbi.nlm.nih.gov/12937682/) and the [normal- and cancer-cell comparison](https://pubmed.ncbi.nlm.nih.gov/40908429/) make a useful pair. The full list follows.

## References

[1] Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice https://pubmed.ncbi.nlm.nih.gov/14501183/
[2] Peptides of pineal gland and thymus prolong human life https://pubmed.ncbi.nlm.nih.gov/14523363/
[3] Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells https://pubmed.ncbi.nlm.nih.gov/12937682/
[4] Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity https://pubmed.ncbi.nlm.nih.gov/40908429/
[5] Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties https://pubmed.ncbi.nlm.nih.gov/40141333/
[6] Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture https://pubmed.ncbi.nlm.nih.gov/22816096/
[7] Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats https://pubmed.ncbi.nlm.nih.gov/12049808/
[8] Effect of epitalon on the lifespan increase in Drosophila melanogaster https://pubmed.ncbi.nlm.nih.gov/11087911/

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Keystone Peptide is my argument with the published Epitalon experiments, especially the mouse near the middle of the group, and these essays provide no medical advice.