Reading list
Survival, cells and the preparations studied
The mouse experiment is the starting point. The cell findings and the human follow-up make the argument more complicated.
Starting with survival
The female SHR mouse paper is the best introduction to the argument here because its maximum and mean lifespan findings pull attention in different directions. The human follow-up is worth opening alongside it, with Epithalamin still in its name.
For the cellular work, the fetal fibroblast experiment and the normal- and cancer-cell comparison make a useful pair. The full list follows.
- Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice ↗
- Peptides of pineal gland and thymus prolong human life ↗
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells ↗
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity ↗
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties ↗
- Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture ↗
- Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats ↗
- Effect of epitalon on the lifespan increase in Drosophila melanogaster ↗